The MPEP is based on the USPTO rules, 37 Code of Federal Regulations, federal court cases, and federal patent law, Title 35 of the United States Code.
The MPEP informs patent attorneys, agents, and examiners how to interpret rules and laws in detailed situations that arise during prosecution of a patent application in the PTO. For example, Chapter 2100 of the MPEP tells how to persuade an examiner as to the basis for granting a patent for a given US patent application. I have found it helpful in my practice as a patent attorney.
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